Preparation of enzymatically active sponges or foams for detoxification of hazardous compounds

US6642037B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Richard K. Gordon · Potomac, US
• Bhupendra P. Doctor · Potomac, US
• Ashima Saxena · Fairfax, US
• Shawn R. Feaster · Duluth, US
• Donald Maxwell · Baltimore, US
• Michelle Ross · Edgewood, US
• David Lenz · Bel Air, US
• Keith E. LeJeune · Murrysville, US
• Alan J. Russell · Boulder, US

Key dates

• Filing date: Apr 26, 2000
• Grant date: Nov 4, 2003
• Expiry date: Apr 26, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2110/0083
• WIPO field: Machine tools
• WIPO sector: Mechanical engineering

Abstract

An enzymatically active reusable sponge or foam, capable of regeneration with oximes, made of a polymer such as polyurethane is prepared for detoxification of hazardous compounds such as organophosphorus and organosulfur compounds. The foam or sponge contains a plurality of enzymes including enzymes selected from acetylcholinesterase, butyrylcholinesterase, triesterase, pseudocholinesterase, organophosphate hydrase, phosphotriesterase, paraoxonase and organophosphorus and organosulfur hydrolyzing enzymes. The sponge or foam may additionally contain activated carbon and an enzyme reactivation compound. A kit can be formed containing the sponge or foam and the compound for enzyme reactivation. The enzymatically active foam or sponge may be prepared using a two chamber device where enzymes and prepolymer are passed from separate chambers into a static mixing stator and are subjected to low shear mixing and extrusion to form by the sponge or foam.