Enhancement of vascular function by modulation of endogenous nitric oxide production or activity

US6642208B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• John Cooke · Palo Alto, US
• Victor J. Dzau · Newton, US
• Gary H. Gibbons · Atlanta, US

Key dates

• Filing date: Aug 15, 2001
• Grant date: Nov 4, 2003
• Expiry date: Oct 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.