Benzo[b]pyrano[3,2-h]acridin-7-one compounds

US6642248B2 · kind B2 · utility

Assignee

• LES LABORATOIRES SERVIER · FR

Inventors

• Michel Koch · La Celle-Saint-Cloud, FR
• François Tillequin · Paris, FR
• Sylvie Michel · Paris, FR
• Elisabeth Seguin · Paris, FR
• Abdelhakim El Omri · Rouen, FR
• John Hickman · Paris, FR
• Alain Pierre · Marly-le-Roi, FR
• Bruno Pfeiffer · Eaubonne, FR
• Pierre Renard · Versailles, FR

Key dates

• Filing date: Jul 25, 2002
• Grant date: Nov 4, 2003
• Expiry date: Jul 25, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound selected from those of formula (I): wherein:X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description,R1 represents hydrogen or alkyl,R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore,R3 and R4 represent hydrogen or alkyl,W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containi…