Acid derivatives useful as serine protease inhibitors

US6642252B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Gregory S. Bisacchi · Lawrenceville, US
• James Sutton · Princeton Junction, US
• William A. Slusarchyk · Montgomery, US
• Uwe D. Treuner · Etterzhausen, DE
• Guohua Zhao · Princeton, US
• Daniel L. Cheney · Ringoes, US
• Yan Shi · Flourtown, US
• Shung C. Wu · Princeton, US

Key dates

• Filing date: Nov 7, 2001
• Grant date: Nov 4, 2003
• Expiry date: Nov 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the formula (I), are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, IXa, Xa, and/or XIa, wherein ring B is phenyl or pyridyl, W is preferably C(═O)NR4R5, L is a linker group, X2 comprises nitrogen or carbon, Z is an optionally-substituted monocyclic or bicyclic ring system, and R1, R2, R3, R4, R5 and R6 are as defined in the specification.