Modulators of Rho C activity

US6642263B2 · kind B2 · utility

Assignee

• Iconix Pharmaceuticals, Inc. · US

Inventors

• Dongxu Sun · Cupertino, US
• Edward Perkins · Savannah, US
• Stuart Tugendreich · Mountain View, US
• Ving J. Lee · Airmont, US

Key dates

• Filing date: Nov 19, 2002
• Grant date: Nov 4, 2003
• Expiry date: Nov 19, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula 1 modulate the activity of Rho C: whereinn is 2 to 5, inclusive; R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H, halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl, or lower alkylenedioxy; andpharmaceutically acceptable salts thereof.