Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates
US6642366B1 · kind B1 · utility
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17Claims
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Key dates
| Filing date | Jun 7, 2002 |
| Grant date | Nov 4, 2003 |
| Priority date | — |
| Expiry date | Jun 7, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for manufacturing morphine-6-glucuronide and related compounds of the general structure of Formula 1: wherein optionally substituted morphine is conjugated with an optionally substituted member of a new class of intermediates, namely, 1-haloglucuronate esters, in the presence of iodine or an iodinium compound. The conjugation may be followed by conversion of R1 of Formula 1 into hydrogen and/or the removal of the ester groups from the glucuronic residue at R2 of Formula 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.