Patent · US Expired

Photocleavable and acid cleavable linkers for combinatorial chemistry

US6642417B2 · kind B2 · utility

0Cited by

2References

19Claims

0Family size

Assignee

Pharmacopeia Drug Discovery, Inc. · US

Inventors

Vinh D. Tran · Willow View Lane, US
Vu Van Ma · Simi Valley, US
Ruiyan Liu · Yardley, US

Key dates

Filing date	Jan 22, 2001
Grant date	Nov 4, 2003
Priority date	—
Expiry date	Jan 25, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/11
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R1 is —NO2 or —CHO; R2 is —OCH3, —CHO or —H; R3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3-12. A substrate of solid phase synthesis of the formula III is also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.