Compositions of saponin adjuvants and excipients
US6645495B1 · kind B1 · utility
23Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 1998 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Aug 28, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55577
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Certain novel compositions of the adjuvant saponin QS-21 having improved properties are disclosed. The compositions of the present invention are designed (1) to minimize the lytic effects of QS-21, (2) to improve the tolerance of QS-21 containing formulations in humans or other animals, (3) to stabilize the QS-21 from alkaline hydrolysis and/or (4) to maintain the high adjuvant potency of the QS-21 product. These compositions may be employed with vaccines comprising proteins or peptides, polysaccharides, lipids, or nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.