Carbonyl reductase, gene thereof and method of using the same
US6645746B1 · kind B1 · utility
133Cited by
1References
15Claims
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Key dates
| Filing date | Nov 19, 2001 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Nov 19, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel polypeptide for producing tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate, a gene encoding the polypeptide, and a method of using the polypeptide, are provided. The polypeptide has an enzyme activity to asymmetrically reduce tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate to tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate. The polypeptide comprises the amino acid sequence represented by SEQ ID NO. 1 in the Sequence Listing, or the amino acid sequence having at least one amino acid substitution, insertion, deletion, or addition thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.