DSP-5 dual-specificity phosphatase
US6645753B1 · kind B1 · utility
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17Claims
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Key dates
| Filing date | Apr 24, 2000 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Apr 24, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/03048
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.