Benzimidazole vascular damaging agents
US6645950B1 · kind B1 · utility
2Cited by
5References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 22, 2001 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Oct 22, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D235/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula I wherein A represents a multi-substituted alkyl group or aromatic ring.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.