Indolizine SPLA2inhibitors
US6645976B1 · kind B1 · utility
9Cited by
1References
32Claims
0Family size
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Key dates
| Filing date | Apr 28, 1997 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Apr 28, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A class of novel indolizine-1-functional compounds and indolizine-3-functional compounds is disclosed together with the use of such indolizine compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indolizine-1-acetamides, indolizine-1-acetic acid hydrazides, indolizine-1-glyoxylamides, indolizine-3-acetamides, indolizine-3-acetic acid hydraxides, and indolizine-3-glyoxylasides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.