Dextran derivatives, preparation and medicinal applications

US6646120B1 · kind B1 · utility

Assignee

• BIODEX · US

Inventors

• Frederic Chaubet · Eaubonne, FR
• Remi Huynh · Saint-Amand-les-Eaux, FR
• Latifa Dahri · Saint-Amand-les-Eaux, FR
• Jose Correia · Saint-Amand-les-Eaux, FR
• Marcel Jozefowicz · Persan, FR
• Jacqueline Jozefonvicz · Persan, FR

Key dates

• Filing date: Sep 26, 2000
• Grant date: Nov 11, 2003
• Expiry date: Sep 26, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.1 provided that when d=0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.