Peptides and proteins for desensitizing subjects allergic to bee venom and compositions containing same

US6649166B1 · kind B1 · utility

Assignee

• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

• Bernard Maillere · Versailles, FR
• Sandra Pouvelle · Nozay, FR
• Catherine Texier · Orsay, FR
• Andre Menez · Voisins-le-Bretonneux, FR

Key dates

• Filing date: Mar 28, 2002
• Grant date: Nov 18, 2003
• Expiry date: Mar 28, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns peptides and proteins for desensitizing specifically the vast majority of subjects allergic to bee venom and compositions containing said peptides or proteins. The peptides are selected in the group consisting of: the fragment (1) corresponding to positions P85-97 of the major bee venom allergen, the fragment (2) corresponding to positions P81-93 of the major bee venom allergen, the fragment (3) corresponding to positions P94-106 of the major bee venom allergen, the fragment (4) corresponding to positions P76-88 of the major bee venom allergen, the fragment (5) corresponding to positions P77-94 of the major bee venom allergen, and the fragment (6) corresponding to positions P122-134 of the major bee venom allergen, fragments (I) and (2) forming group (1); fragment (3) forming group (II); fragments (4) and (4) forming group (III) and fragment (6) forming group IV and the mutated fragments of said fragments (1) to (6) which have a binding activity with MHC class (II) molecules identical or higher than those of said fragments (1) to (6). The invention also concerns compositions containing said peptides or proteins.