Diacylhydrazine derivatives

US6649613B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Gunter Holzemann · Seeheim-Jugenheim, DE
• Simon Goodman
• Horst Kessler · Schwalbach, DE
• Christoph Gibson · Munich, DE
• Gabor Sulyok · Munich, DE

Key dates

• Filing date: Jan 14, 2002
• Grant date: Nov 18, 2003
• Expiry date: Jan 14, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to combat thromboses, myocardial infarcts, coronary cardiac diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections, and restenosis following angioplasty or during pathological processes that are maintained or propagated by angiogenesis.