Phenoxylpropanolamines, method for the production thereof and pharmaceutical compositions containing the same

US6649627B1 · kind B1 · utility

Assignee

• Sanofi-Synthelabo · FR

Inventors

• Roberto Cecchi · Lodi, IT
• Tiziano Croci · Milano, IT
• Umberto Guzzi · Milano, IT
• Eric Marsault · Montréal, CA

Key dates

• Filing date: Mar 26, 2001
• Grant date: Nov 18, 2003
• Expiry date: Mar 26, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of formula (Ia) whereinR1a represents hydrogen, an —S(O)z —(C1-C4)Alk group, a —CO(C1-C4)Alk group, an —NHSO2—(C1-C4)Alk group, an NCHl (C1-C4) Alk group, a 2-furyl group or a halogen;R2 represents hydrogen or a (C1-C4)Alk group, a (C1-C4) alkoxyl group, a halogen, —COOH, —COO(C1-C4)Alk, —CN, —CONR3R4, —NO2, —SO2NH2, —NHSO2(C1-C4)Alk;m and n are independently 0, 1 or 2;R3 and R4 independently represent hydrogen or a (C1-C4)Alk group;Z is 1 or 2and their salts or solvates, the pharmaceutical compositions that contain them, the process for their preparation, and intermediate synthesis products.