Succinate derivative compounds useful as cysteine protease inhibitors

US6649642B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Younes Bekkali · Danbury, US
• Eugene Richard Hickey · Danbury, US
• Weimin Liu · Sandy Hook, US
• David Thomson · Ridgefield, US

Key dates

• Filing date: Oct 23, 2002
• Grant date: Nov 18, 2003
• Expiry date: Oct 23, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.