Patent · US Expired

Trioxane derivatives

US6649647B1 · kind B1 · utility

12Cited by

2References

7Claims

0Family size

Inventors

Richard K. Haynes · Kowloon, CN
Ho-Wai Chan · Tsuen Wan, CN
Wai-Lun Lam · Kowloon, CN
Hing-Wo Tsang · Sha Tin, CN
Wen Luan Wendy Hsiao · Macau, CN
Hans-Georg Lerchen · Leverkusen, DE
Jorg Baumgarten · Wuppertal, DE

Key dates

Filing date	Apr 15, 2002
Grant date	Nov 18, 2003
Priority date	—
Expiry date	Apr 15, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D493/20
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention relates to compounds containing a trioxane moiety, especially certain artemisinin derivatives, which have cytotoxic and antitumour activity and their use in the treatment of cancer. Some of these compounds comprise a ligand which is capable of binding to a nucleic acid and a group containing a trioxane moiety which is capable of acting as source of free radicals which are capable of chemically interacting with a nucleic acid. Processes for the preparation of such compounds and pharmaceutical compositions containing such compounds are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.