Patent · US Expired

Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols

US6649783B2 · kind B2 · utility

2Cited by

9References

13Claims

0Family size

Assignee

Euro-Celtique S.A. · LU

Inventors

Robert Kupper · Mount Airy, US
Andreas Stumpf · Leverkusen, DE

Key dates

Filing date	Oct 3, 2001
Grant date	Nov 18, 2003
Priority date	—
Expiry date	Jun 12, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol, are disclosed herein. In one embodiment, the (±)-2-((dimethylamino)methyl)cyclohexanone and transition-metal salt are in the form of a (±)-2-((dimethylamino)methyl)cyclohexanone:transition-metal salt complex. In another embodimemt, aryl is 3-methoxyphenyl.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.