Targeting multimeric imaging agents through multilocus binding
US6652835B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 2000 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Jul 28, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites. The compounds consist of:a) two or more Image Enhancing Moieties (IEMs) (or signal-generating moiety) comprising multiple subunits;b) two or more Target Binding Moieties (TBMs), providing for in vivo localization and multimer rigidification; andc) a scaffold framework for attachment of the above moieties.d) optional linkers for attachment of the IEMs to scaffold.This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement of diagnostic imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.