Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics

US6652876B2 · kind B2 · utility

Assignee

• BEIERSDORF AG · DE

Inventors

• Detlev Radloff · Hamburg, DE
• Matthias Wasner · Reinbek, DE

Key dates

• Filing date: Dec 21, 2000
• Grant date: Nov 25, 2003
• Expiry date: Feb 22, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T442/2525
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed ofa) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene,b) from 5 to 40% by weight of amorphous poly-&agr;-olefin,c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 &mgr;m, andd) from 0.001 to 20% by weight of a drug.