Method for identifying compounds useful in the therapy of bone disorders
US6653064B1 · kind B1 · utility
18Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 25, 2000 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Sep 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2217/05
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a screening method for identifying a substance for the treatment of bone disorders that are associated with reduced bone mass in which the substance is tested for its ability to upregulate the expression of Fra-1 or to modulate the expression of a Fra-1 target gene in osteoblasts where the upregulation or modulation results in an increased bone formation in vivo. The identified osteoinductive compounds and DNA molecules encoding biologically active Fra-1 molecules can be used for the therapy of bone disorders characterized by a circumscribed or systemic reduction of bone mass.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.