Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
US6653094B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2001 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Nov 22, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6893
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.