Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases

US6653304B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Katerina Leftheris · Skillman, US
• Hong Wu · Meekrap-oord, CN
• Stephen T. Wrobleski · Whitehouse Station, US
• Ping Chen · San Diego, US
• John Hynes · Washington Crossing, US
• John S. Tokarski · Princeton, US

Key dates

• Filing date: Feb 8, 2001
• Grant date: Nov 25, 2003
• Expiry date: Feb 8, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R1-R6 are as defined in the specification, wherein R2 with R5 may form a ring, and/or two R4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R6 forming a ring with R3.