Naphthylsulfonic acids and related compounds as glucose uptake agonists

US6653321B1 · kind B1 · utility

Assignee

• Telik, Inc. · US

Inventors

• Wayne Spevak · Berkeley, US
• Songyuan Shi · Fremont, US
• Prasad Manchem · South San Francisco, US
• Michael R. Kozlowski · Palo Alto, US
• Steven R. Schow · Washingtonville, US
• Robert T. Lum · Palo Alto, US
• Louise Robinson · Redwood City, US
• Jeong Weon Park · Emeryville, US

Key dates

• Filing date: Jul 28, 2000
• Grant date: Nov 25, 2003
• Expiry date: Jul 28, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/85
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.