Human hypoxanthine- (guanine) phosphoribosyl transferase-2
US6653446B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1998 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Nov 12, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.