Method for the manufacture of Anagrelide
US6653500B2 · kind B2 · utility
5Cited by
8References
6Claims
0Family size
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Key dates
| Filing date | Apr 25, 2002 |
| Grant date | Nov 25, 2003 |
| Priority date | — |
| Expiry date | Apr 25, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C227/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.