Sciellin and uses thereof
US6656705B1 · kind B1 · utility
0Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1999 |
| Grant date | Dec 2, 2003 |
| Priority date | — |
| Expiry date | Mar 26, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel epidermal protein, sciellin. Sciellin polypeptides comprise an N-terminal domain, a central domain containing sixteen repeats and a C-terminal LIM domain. Sciellin polypeptides may function as precursors of the cornified envelope of keratinizing tissues. Described herein are isolated and antisense nucleic acids molecules, recombinant expression vectors, host cells and non-human transgenic animals containing an insertion or a disruption of the sciellin gene. Diagnostic, screening and therapeutic methods utilizing the compositions of the invention are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.