Compositions for the delivery of polynucleotides to cells
US6656734B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1998 |
| Grant date | Dec 2, 2003 |
| Priority date | — |
| Expiry date | Jun 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/87
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a composition which is intended for transferring at least one therapeutically active substance into the interior of a target cell, characterized in that it comprises a mixture of at least one therapeutically active substance and at least one polar compound which is selected from a specific group of aprotic polar compounds. The therapeutically active substance is preferably a polynucleotide, and the polar compound is DPSO, which improves the ability of the polynucleotide to be transfected into the interior of the cells. The compositions according to the invention can be used as a diagnostic therapeutic, prophylactic or vaccinal medicament for treating the human or animal body by means of gene therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.