Fatty acid transport proteins
US6657049B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 14, 1999 |
| Grant date | Dec 2, 2003 |
| Priority date | — |
| Expiry date | Jan 14, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/044
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Isolated antibodies and antigen-binding fragments thereof which specifically bind to members of a family of fatty acid transport proteins (FATPs) which mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells are described. These proteins exhibit different expression patterns among the organs of mammals. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.