Human antibodies derived from immunized xenomice
US6657103B1 · kind B1 · utility
126Cited by
10References
4Claims
0Family size
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Key dates
| Filing date | Sep 4, 1997 |
| Grant date | Dec 2, 2003 |
| Priority date | — |
| Expiry date | Sep 4, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.