Transgenic mouse model for cardiac hypertrophy and methods of use thereof
US6657104B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 15, 1998 |
| Grant date | Dec 2, 2003 |
| Priority date | — |
| Expiry date | Oct 15, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4712
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.