Sustained-release microgranules containing diltiazem as active principle

US6660296B2 · kind B2 · utility

Assignee

• Laboratoires des Prodiuts Ethiques Ethypharm · FR

Inventors

• Patrice Debregeas · Paris, FR
• Gerard Leduc · Nemours, FR
• Pascal Oury · Le Chesnay, FR
• Pascal Suplie · Montaure, FR

Key dates

• Filing date: Dec 3, 2001
• Grant date: Dec 9, 2003
• Expiry date: Dec 3, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel forms of sustained-release microgranules (LP) containing diltiazem are disclosed. The microgranules consist of a neutral granular carrier coated with an active layer including diltiazem or a pharmaceutically acceptable salt thereof as the active principle, a surfactant and a binder, and an outer layer providing sustained release of the active principle (layer LP).