Chimeric serine proteases

US6660492B1 · kind B1 · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfram Bode · Gauting, DE
• Richard Engh · Weßling, DE
• Karl-Peter Hopfner · Starnberg, DE
• Robert Huber · Midland, US
• Erhard Kopetzki · Penzberg, DE

Key dates

• Filing date: Sep 18, 2000
• Grant date: Dec 9, 2003
• Expiry date: Feb 24, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a &bgr;-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half corresponds to the second domain half of a second serine protease, has improved properties and can be readily crystallized.