Reagents useful for detecting diseases of the gastrointestinal tract

US6660834B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Patricia Billing-Medel · Gurnee, US
• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Paula Friedman · Deerfield, US
• Julian Gordon · Lake Bluff, US
• Edward Granados · Vernon Hills, US
• Mark A. Hayden · Ingleside, US
• Steven Hodges · Buffalo Grove, US
• Michael Klass · Libertyville, US
• Jon Kratochvil · Wildwood, US
• Lisa Roberts-Rapp · Gurnee, US
• John Russell · Pleasant Prairie, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: Oct 23, 2002
• Grant date: Dec 9, 2003
• Expiry date: Oct 23, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/828
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.