Modified peptides as therapeutic agents
US6660843B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1999 |
| Grant date | Dec 9, 2003 |
| Priority date | — |
| Expiry date | Oct 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising:a) selecting at least one peptide that modulates the activity of a protein of interest; andb) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide.Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide is preferably selected by phage display, E. coli display, ribosome display, RNA-peptide screening, or chemical-peptide screening.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.