Modified Morbillivirus V proteins
US6664066B2 · kind B2 · utility
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34Claims
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Key dates
| Filing date | Dec 16, 2002 |
| Grant date | Dec 16, 2003 |
| Priority date | — |
| Expiry date | Dec 16, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18461
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described, wherein one or both of amino acids 113 or 114 is mutated. Such modified Morbilliviruses exhibit reduced repression of gene expression. Additional mutations or deletions in other regions of the genome may be included, including in the carboxy-terminal region.
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