Bicyclic vasopressin agonists

US6664249B1 · kind B1 · utility

Assignee

• Ferring B.V. · NL

Inventors

• Doreen Ashworth · Southampton, GB
• Gary Robert William Pitt · Melbourne, AU
• Peter Hudson · Germantown, US
• Christopher Martyn YEA · Romsey, GB
• Richard Jeremy Franklin · Wokingham, GB

Key dates

• Filing date: Jun 10, 2002
• Grant date: Dec 16, 2003
• Expiry date: Jun 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds according to general formula (1), and pharmaceutically acceptable salts thereof, wherein V is a covalent bond or NH, X is selected from CH2, O and N-alkyl, Z is either S or —CH═CH—, R1 and R2 are independently selected from H, F, Cl, Br and alkyl, R3 is selected from OH, O-alkyl and NR4R5, R4 and R5 are each independently H or alkyl, or together are —(CH2)q—, p is 0, 1, 2, 3 or 4, and q is 4 or 5, are new. They are agonists at the asopressin V2 receptor and are useful as antidiuretics and pro-coagulants.