Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

US6664255B1 · kind B1 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Michael S. South · Chesterfield, US
• John J. Parlow · Arnold, US
• Darin E. Jones · Ballwin, US
• Brenda Case · Chesterfield, US
• Tom Dice · Holden, US
• Richard Lindmark · Chesterfield, US
• Michael Hayes · Chesterfield, US
• Melvin L. Rueppel · Chesterfield, US
• Horng-Chih Huang · Chesterfield, US
• Wei Huang · Wildwood, US
• Scott Long · Holden, US
• Matthew Mahoney · Saint Peters, US
• William L. Neumann · Chesterfield, US
• David B. Reitz · Chesterfield, US
• John I. Trujillo · Ledyard, US
• Ching-Cheng Wang · New Taipei, TW
• Rhonda Wood · Maryland Heights, US
• Qingping Zeng · Thousand Oaks, US
• Rick Fenton · Collinsville, US
• Gary W. Franklin · Godfrey, US
• Carrie Kusturin · Edwardsville, US

Key dates

• Filing date: May 18, 2000
• Grant date: Dec 16, 2003
• Expiry date: May 18, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.