Crystalline fluoroquinolone arginine salt form

US6664267B1 · kind B1 · utility

Assignee

• Wockhardt Limited · IN

Inventors

• Noel De Souza · Mumbai, IN
• Prasad Keshav Deshpande · Aurangabad, IN
• Milind Shukla · Aurangabad, IN
• Siddiqui Jaweed Mukarram · Aurangabad, IN
• Dilip Ganesh Kulkarni · Aurangabad, IN
• Ansari Azizur Rahman · Aurangabad, IN
• Ravindra Dattatraya Yeole · Aurangabad, IN
• Mahesh Vithalbhai Patel · Aurangabad, IN
• Shrikant Gupte · Aurangabad, IN

Key dates

• Filing date: May 28, 2002
• Grant date: Dec 16, 2003
• Expiry date: May 28, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating microbial infections.