Chromatography material and a process of manufacturing that material

US6664305B2 · kind B2 · utility

Assignee

• Bia Separations d.o.o. · SI

Inventors

• Alois Jungbauer · Wien, AT
• Rainer Hahn · Tübingen, DE
• Ales Podgornik · Ljubljana, SI
• Milos Barut · Ljubljana, SI
• Ales Strancar · Lilltjärnen, SI

Key dates

• Filing date: Oct 28, 2002
• Grant date: Dec 16, 2003
• Expiry date: Oct 28, 2022

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2220/82
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A process of manufacturing of a chromatography material comprising the steps of(i) reacting a polymerizable at least bifunctional monomer A with a ligand also having a functional group which binds covalently with one of the functional groups of said polymerizable bifunctional monomer A,(ii) to form a compound B comprising at least one polymerizable functional moiety(iii) polymerizing the compound B essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting or(iv) reacting the ligand and a spacer via a covalent bond which is cleavable to form a ligand-spacer conjugate and binding the ligand-spacer conjugate to the surface of a chromatographic support or reacting the ligand-spacer conjugate via a covalent bond to the at least bi-functional monomer A and polymerizing it essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting.