N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them

US6664393B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Otmar Klingler · Rodgau, DE
• Gerhard Zoller · Blankenloch, DE
• Elisabeth Defossa · Idstein, DE
• Fahad Al-Obeidi · Tucson, US
• Armin Walser · Tucson, US
• James Ostrem · Tucson, US

Key dates

• Filing date: Aug 26, 2002
• Grant date: Dec 16, 2003
• Expiry date: Aug 26, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formula I, in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa and/or factor VIIa and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of conditions in which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.