Compound assay
US6664441B1 · kind B1 · utility
2Cited by
0References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2000 |
| Grant date | Dec 16, 2003 |
| Priority date | — |
| Expiry date | Apr 14, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/43534
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.