Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
US6667161B1 · kind B1 · utility
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8Claims
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Key dates
| Filing date | Oct 5, 1999 |
| Grant date | Dec 23, 2003 |
| Priority date | — |
| Expiry date | Oct 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.