Method for protecting cells and tissues from ionizing radiation toxicity with &agr;, &bgr; unsaturated aryl sulfones

US6667346B2 · kind B2 · utility

Assignees

• Temple University-Of The Commonwealth System of Higher Education · US
• ONCONOVA THERAPEUTICS, INC. · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US
• Stephen Cosenza · Voorhees, US
• Lawrence Helson · Quakertown, US

Key dates

• Filing date: Feb 28, 2002
• Grant date: Dec 23, 2003
• Expiry date: Feb 28, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.