Process for the preparation of &agr;-haloketones

US6667422B2 · kind B2 · utility

Assignee

• Consortium für elektrochemische Industrie GmbH · DE

Inventors

• Dieter Heldmann · Munich, DE
• Juergen Stohrer · Pullach, DE

Key dates

• Filing date: Sep 3, 2002
• Grant date: Dec 23, 2003
• Expiry date: Sep 3, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing an &agr;-haloketone of the formula (1) where R1 is an optionally heteroatom-containing and optionally substituted hydrocarbon radical,R2 is a hydrogen, alkyl, aralkyl or aryl radical, andX is a halogen radical,by reacting a carboxylic acid derivative of the general formula (2) where L is a leaving group,with a mono- or dienolate of a silyl ester of the formula (3) where R3 and R4 are identical or different alkyl, aryl, alkenyl or aralkyl radicals;and hydrolyzing the reaction product immediately afterwards by adding acid and decarboxylating to (1). The product &agr;-haloketone may be reduced to the corresponding &agr;-haloalcohol.