Patent · US Expired

Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use

US6670147B1 · kind B1 · utility

27Cited by

4References

7Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Hans Heinrich Heidtmann · Meiningen, DE
Rolf Mueller · Ingolstadt, DE
Hans-Harald Sedlacek · Marburg, DE

Key dates

Filing date	Feb 24, 1999
Grant date	Dec 30, 2003
Priority date	—
Expiry date	Feb 24, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.