Protein and gene involved in myocyte differentiation
US6670450B1 · kind B1 · utility
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6Claims
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Key dates
| Filing date | Oct 6, 2000 |
| Grant date | Dec 30, 2003 |
| Priority date | — |
| Expiry date | Oct 6, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A gene was unexpectedly isolated in an attempt to isolate a gene specifically expressed in immortalized cells via antibody screening using an antibody raised against a protein occurring specifically in immortalized cells. The gene thus isolated shares no sequence homology with the entries deposited in the database and was strongly expressed in skeletal muscles and undifferentiated cells. The protein encoded by this gene inhibits the differentiation of myoblasts into myotubes. It also inhibits the transactivation function of p53, a transcription factor involved in tumor suppression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.