Methods and compositions for treating diseases due to androgen deficiency with glucocorticoid receptor antagonist compounds and new compounds

US6670493B2 · kind B2 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Vladimir Patchev · Jena, DE
• Lothar Sobek · Jena, DE
• Gerd Schubert · Jena, DE

Key dates

• Filing date: Aug 13, 2002
• Grant date: Dec 30, 2003
• Expiry date: Aug 13, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0083
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The method of treating or preventing a disease in a human male or a male animal caused by a decreased production of androgens, such as testosterone, in the human male or male animal includes administering an effective amount of a glucocorticoid receptor antagonist to the human male or the male animal in order to increase production of the androgens. These diseases include male sexual dysfunction, infertility and hypogonadism. Novel androgen receptor antagonist compounds and methods of synthesis are also described.