Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6673335B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2000 |
| Grant date | Jan 6, 2004 |
| Priority date | — |
| Expiry date | Jul 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (%w) water, usually below about 5%w and preferably less than about 3%w; a particle size of about 1.0-5.0 &mgr;m mass median diameter (MMD), usually 1.0-4.0 &mgr;m MMD, and preferably 1.0-3.0 &mgr;m MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 &mgr;m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 &mgr;m MMAD, and preferably 1.5-4.0 &mgr;m MMAD. Such compositions are of pharmaceutical grade purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.